4,4'-Difluorobenzophenone → (4-Aminophenyl)(4-fluorophenyl)methanone

HRID 490015Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 490015
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)([OH:11])C#C)=[CH:4][CH:3]=1.FC1C=CC(C(C2C=CC(F)=CC=2)=O)=CC=1>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[O:11])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 95824,4'-DifluorobenzophenoneHCID 876134721-(4-Aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol

Produkt 1

HCID 577826(4-Aminophenyl)(4-fluorophenyl)methanone

Versuchsvorschrift

Referring now to FIG. 2, wherein one non-limiting approach to the 1-(4-aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol is presented, 4,4′-difluorobenzophenone (7) is reacted with a secondary amine HNR′″R″″ to give the 4-amino-4′-fluorobenzophenone 8, where R′″ and R″″ may be the same as R36 and R37, respectively, as set forth and claimed herein. Acetylide anion, for example, sodium acetylide in acetylene saturated dimethylformamide, is added to the carbonyl of 4-amino-4′-fluorobenzophenone 8 to give, upon aqueous workup, 1-(4-aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol 9.

Quellen und Nachweise

ORD-Eintrag
ord-bc6840b61a2f47df85eb97f708fd6de6
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07527754B2

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