Trifluoroacetic acid → HCID 67428691, Verbindung

HRID 490122Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 490122
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][N:9]([CH3:25])[C:10]([C@@H:12]1[CH2:16][C@@H:15]([F:17])[CH2:14][N:13]1C(OC(C)(C)C)=O)=[O:11]>C(Cl)(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:17][C@H:15]1[CH2:14][NH:13][C@H:12]([C:10]([N:9]([CH3:25])[CH3:8])=[O:11])[CH2:16]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 67428750tert-butyl(2S,4R)-2-[(dimethylamino)carbonyl]-4-fluoropyrrolidine-1-carboxylate

Produkt 1

HCID 67428691HCID 67428691, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

10.5 mL of trifluoroacetic acid was added under ice cooling to a 25 mL chloroform solution of 3.50 g of the compound obtained in step 1-2b, after which the reaction mixture was stirred for 3 hours at room temperature. The solvent was then distilled off under reduced pressure, which gave 7.27 g of residue (yellow oily substance). This compound was used in the following reaction without being purified.

Aufarbeitung

  1. distillationThe solvent was then distilled off under reduced pressure, which

Quellen und Nachweise

ORD-Eintrag
ord-41e6913884764ba088bed494a1fcd2e2
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528124B2

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