Trifluoroacetic acid → 4,4-difluoro-N,N-dimethyl-L-prolinamide trifluoroacetate

HRID 490128Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 490128
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][N:9]([CH3:26])[C:10]([C@@H:12]1[CH2:16][C:15]([F:18])([F:17])[CH2:14][N:13]1C(OC(C)(C)C)=O)=[O:11]>C(Cl)(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:18][C:15]1([F:17])[CH2:14][NH:13][C@H:12]([C:10]([N:9]([CH3:8])[CH3:26])=[O:11])[CH2:16]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 25178383BOC-4,4-difluoroproline-N,N-dimethylamide

Produkt 1

HCID 674283014,4-difluoro-N,N-dimethyl-L-prolinamide trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

11 mL of trifluoroacetic acid was added under ice cooling to a 40 mL chloroform solution of 3.85 g of the compound obtained in step 3-4, and the reaction mixture was stirred for 2 hours at room temperature. The solvent was then distilled off under reduced pressure to obtain 8.02 g of residue (pale yellow oily substance). This compound was used in the following reaction without being purified.

Aufarbeitung

  1. distillationThe solvent was then distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e507d1faf8cf47ee96c626590ec66f0d
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528124B2

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