Trifluoroacetic acid → 4-fluoro-N,N-dimethyl-D-prolinamide trifluoroacetate

HRID 490134

Reaktionsgleichung

Reaktionsgleichung von HRID 490134
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][N:9]([CH3:25])[C:10]([C@H:12]1[CH2:16][CH:15]([F:17])[CH2:14][N:13]1C(OC(C)(C)C)=O)=[O:11]>C(Cl)(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:17][CH:15]1[CH2:14][NH:13][C@@H:12]([C:10]([N:9]([CH3:25])[CH3:8])=[O:11])[CH2:16]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 69064202tert-butyl(2R)-2-[(dimethylamino)carbonyl]-4-fluoropyrrolidine-1-carboxylate

Produkt 1

HCID 690618314-fluoro-N,N-dimethyl-D-prolinamide trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

10 mL of trifluoroacetic acid was added under ice cooling to a 30 mL chloroform solution of 2.09 g of the compound obtained in step 6-2, after which the reaction mixture was stirred for 2 hours at room temperature. The reaction mixture was then concentrated under reduced pressure, which gave 3.42 g of residue (pale yellow oily substance). This compound was used in the following reaction without being purified.

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated under reduced pressure, which

Quellen und Nachweise

ORD-Eintrag
ord-cd9a3c58831a439fa2eb5c0b3085fd58
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528124B2

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