Trifluoroacetic acid → (2S)-2-(azetidin-1-ylcarbonyl)-4-fluoropyrrolidine trifluoroacetate

HRID 490137Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 490137
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[N:8]1([C:12]([C@@H:14]2[CH2:18][CH:17]([F:19])[CH2:16][N:15]2C(OC(C)(C)C)=O)=[O:13])[CH2:11][CH2:10][CH2:9]1>C(Cl)(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[N:8]1([C:12]([C@@H:14]2[CH2:18][CH:17]([F:19])[CH2:16][NH:15]2)=[O:13])[CH2:11][CH2:10][CH2:9]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 67429147tert-butyl(2S)-2-(azetidin-1-ylcarbonyl)-4-fluoropyrrolidine-1-carboxylate

Produkt 1

HCID 67428608(2S)-2-(azetidin-1-ylcarbonyl)-4-fluoropyrrolidine trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

10 mL of trifluoroacetic acid was added under ice cooling to a 30 mL chloroform solution of 2.20 g of the compound obtained in step 7-2, after which the reaction mixture was stirred for 2 hours at room temperature. After this, the reaction mixture was concentrated under reduced pressure to obtain 3.82 g of residue (pale yellow oily substance). This compound was used in the following reaction without being purified.

Aufarbeitung

  1. concentrationAfter this, the reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f2ceda13e2484980918cc2ab2eda90e7
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528124B2

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