Triethylamine → HCID 57674748, Verbindung

HRID 490224Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 490224
C(O[CH:4]=[C:5]([C:8]#[N:9])[C:6]#[N:7])C.Cl.[NH2:11][CH2:12][CH2:13][NH:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1)=[O:16].C(N(CC)CC)C>C(#N)C>[C:6]([C:5]([C:8]#[N:9])=[CH:4][NH:11][CH2:12][CH2:13][NH:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1)=[O:16])#[N:7]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 671522-(Ethoxymethylene)propanedinitrileHCID 23033068N-(2-aminoethyl)-4-fluorobenzamide hydrochloride

Produkt 1

HCID 57674748HCID 57674748, VerbindungAusbeute 68,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel2×

Versuchsvorschrift

After adding acetonitrile (100 mL) and ethoxymethylenemalononitrile (4.5 g) to N-(2-aminoethyl)(4-fluorophenyl)carboxamide hydrochloride (8.3 g), a solution of triethylamine (4.5 g) in acetonitrile (20 mL) was added thereto. After stirring at room temperature for 15 minutes, the solvent was distilled off under reduced pressure, water and ethyl acetate were added to the residue, and the mixture was stirred. The precipitated solid was filtered out to obtain the crude title compound (6.5 g) as a brown solid.

Aufarbeitung

  1. distillationthe solvent was distilled off under reduced pressure, water and ethyl acetate
  2. additionwere added to the residue
  3. stirringthe mixture was stirred
  4. filtrationThe precipitated solid was filtered out

Quellen und Nachweise

ORD-Eintrag
ord-7113afc0302347c893befd036be00967
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528140B2

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