Trifluoroacetic acid → (2-{1-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propyl]-2-p-tolyl-1H-imidazol-4-yl}-ethylamino)-acetic acid

HRID 490264Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 490264
C([O:5][C:6](=[O:46])[CH2:7][NH:8][CH2:9][CH2:10][C:11]1[N:12]=[C:13]([C:39]2[CH:44]=[CH:43][C:42]([CH3:45])=[CH:41][CH:40]=2)[N:14]([CH:16]([C:20]2[N:29]([CH2:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:28](=[O:37])[C:27]3[C:22](=[CH:23][C:24]([Cl:38])=[CH:25][CH:26]=3)[N:21]=2)[CH:17]([CH3:19])[CH3:18])[CH:15]=1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:30]([N:29]1[C:28](=[O:37])[C:27]2[C:22](=[CH:23][C:24]([Cl:38])=[CH:25][CH:26]=2)[N:21]=[C:20]1[CH:16]([N:14]1[CH:15]=[C:11]([CH2:10][CH2:9][NH:8][CH2:7][C:6]([OH:46])=[O:5])[N:12]=[C:13]1[C:39]1[CH:40]=[CH:41][C:42]([CH3:45])=[CH:43][CH:44]=1)[CH:17]([CH3:19])[CH3:18])[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 58861276(2-{1-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propyl]-2-p-tolyl-1H-imidazol-4-yl}-ethylamino)-acetic acid tert-butyl ester

Produkt 1

HCID 21096985(2-{1-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propyl]-2-p-tolyl-1H-imidazol-4-yl}-ethylamino)-acetic acidAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of (2-{1-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propyl]-2-p-tolyl-1H-imidazol-4-yl}-ethylamino)-acetic acid tert-butyl ester (99.6 mg., 0.155 mmol) and trifluoroacetic acid (8 mL) in methylene chloride (4 mL) was stirred at room temperature for 3.0 h. The reaction was concentrated in vacuo and the residue was triturated with diethyl ether and dried to provide the title compound as a white solid (67 mg., 53%). MS(ES+) m/e 584 [M+H]+.

Aufarbeitung

  1. concentrationThe reaction was concentrated in vacuo
  2. customthe residue was triturated with diethyl ether
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-344b926624374dcaaf94f6ca92489664
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528137B2

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