Potassium Carbonate → 1-(2-Hydroxyethyl)-4-(2-fluorophenyl)piperazine

HRID 49031

Reaktionsgleichung

Reaktionsgleichung von HRID 49031
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.I[CH2:15][CH2:16][OH:17].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[OH:17][CH2:16][CH2:15][N:11]1[CH2:12][CH2:13][N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[CH2:9][CH2:10]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 12225IodoethanolHCID 705291-(2-Fluorophenyl)piperazine

Produkt 1

HCID 206351751-(2-Hydroxyethyl)-4-(2-fluorophenyl)piperazineAusbeute 65,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 1-(2-fluorophenyl)piperazine (0.50 g), 2-iodoethanol (0.48 g), and potassium carbonate (1.5 g) in dimethylformamide (7 mL) was heated at reflux for three hours. The solvent was removed in vacuo and the residue was purified by preparative thin-layer chomatography (silica gel, eluting with chloroform/methanol, 9:1), giving the title compound as a yellow oil (0.41 g, 65%). 1H NMR (300 MHz, CDCl3) δ7.09-6.90 (m, 4H), 3.67 (t, 2H, J=5.4 Hz), 3.13 (t, 4H, J=4.7 Hz), 2.76 (br s, 1H), 2.71 (t, 4H, J=4.8 Hz), 2.63 (t, 4H, J=5.4 Hz). 13C NMR (75 MHz, CDCl3) δ156.3 (d, J=244.1 Hz), 140.6 (d, J=8.8 Hz), 125.1 (d, J=3.4 Hz), 123.2 (d, J=8.1 Hz), 119.5 (d, J=2.9 Hz), 116.7 (d, J=20.6 Hz), 60.1, 58.4, 53.6 (2C), 51.2 (d, 2C, J=3.0 Hz).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for three hours
  3. customThe solvent was removed in vacuo
  4. customthe residue was purified by preparative thin-layer chomatography (silica gel, eluting with chloroform/methanol, 9:1)

Quellen und Nachweise

ORD-Eintrag
ord-74e89468e2c345a2a19678b9a39c2698
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06706716B2

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