HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → 5-carboxymethoxy-1H-indole-2-carboxylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | 5-tert-butoxycarbonylmethoxy-1H-indole-2-carboxylic acid ethyl ester | HCID 69587439 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 5-carboxymethoxy-1H-indole-2-carboxylic acid ethyl ester | HCID 69586665 | 101,3% |
Reaktionsschritte
A mixture of 5-tert-butoxycarbonylmethoxy-1H-indole-2-carboxylic acid ethyl ester (2 g, 6 mmol) and trifluoroacetic acid (8 mL) in dichloromethane (8 mL) was stirred at room temperature for 2 hours. The reaction was concentrated to give 1.6 g (97%) of 5-carboxymethoxy-1H-indole-2-carboxylic acid ethyl ester as a light brown solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06706709B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-97e0e3d6a9364f4f8edc82a1239805fa |
| Quellennotiz | uspto-grants-2004_03 |