HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(m-Tolyl)piperazine → [(2s,4s)-1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidin-2-yl]-(4-m-tolyl-piperazin-1-yl)-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(m-Tolyl)piperazine | HCID 83111 | — |
| Edukt | 1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carboxylic acid | HCID 86625301 | — |
| Produkt | [(2s,4s)-1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidin-2-yl]-(4-m-tolyl-piperazin-1-yl)-methanone | HCID 87440142 | 8,5% |
Reaktionsschritte
As described for Example 56d, 1-benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carboxylic acid (65 mg, 0.146 mmol) was converted, using 1-m-tolyl-piperzine instead of 1-(3-trifluoromethyl-phenyl)-piperazine, to the title compound (7.5 mg, 8.5%) as light yellow oil. MS m/e=605.4 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07528136B2 |
| Quelldatensatz | uspto-grants-2009_05 |
| ORD ID | ord-d2d32b50641540d4be6fa03fbb04c6bd |
| Quellennotiz | uspto-grants-2009_05 |