Hydrochloric Acid → 2-Oxo-3-[5-(3-pyrrolidin-1-yl-propyl)-1H-indol-2-ylmethylene]-2,3-dihydro-1H-indole-5-carboxylic acid

HRID 49080Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 49080
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[CH2:7]2)([OH:3])=[O:2].[CH2:14]([N:16]([CH2:31][CH3:32])[CH2:17][CH2:18][CH2:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[NH:25][C:24]([CH:29]=O)=[CH:23]2)[CH3:15].N1CCCCC1.Cl>C(O)C>[O:13]=[C:8]1[C:7](=[CH:29][C:24]2[NH:25][C:26]3[C:22]([CH:23]=2)=[CH:21][C:20]([CH2:19][CH2:18][CH2:17][N:16]2[CH2:31][CH2:32][CH2:15][CH2:14]2)=[CH:28][CH:27]=3)[C:6]2[C:10](=[CH:11][CH:12]=[C:4]([C:1]([OH:3])=[O:2])[CH:5]=2)[NH:9]1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 8082PiperidineHCID 27733182-Oxindole-5-carboxylic acidHCID 220421145-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde

Produkt 1

HCID 695868642-Oxo-3-[5-(3-pyrrolidin-1-yl-propyl)-1H-indol-2-ylmethylene]-2,3-dihydro-1H-indole-5-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 5-carboxy-2-oxindole (35 mg, 0.2 mmol), 5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde (51 mg, 0.2 mmol) and piperidine (0.1 mL) in ethanol (1 mL) was heated at 80° C. for 6 hours. The reaction was acidified with 1N HCl and the precipitate was collected by vacuum filtration, washed with 1N HCl, water and ethanol, dried to give the title compound.

Aufarbeitung

  1. filtrationthe precipitate was collected by vacuum filtration
  2. washwashed with 1N HCl, water and ethanol
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-425992ee689045699c957ea3577f4672
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06706709B2

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