1-Ethyl-N-[(1R)-2-hydroxy-1-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide → 1-Ethyl-N-[4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

HRID 490914Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 490914
[CH2:1]([N:3]1[C:7]2=[N:8][CH:9]=[C:10]([C:19]([OH:21])=O)[C:11]([NH:12][CH:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[C:6]2[CH:5]=[N:4]1)[CH3:2].[NH2:22][C:23]1([CH2:29][OH:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1.C(N1C2=NC=C(C(N[C@H](C3C=CC=CC=3)CO)=O)C(NC3CCOCC3)=C2C=N1)C>>[CH2:1]([N:3]1[C:7]2=[N:8][CH:9]=[C:10]([C:19]([NH:22][C:23]3([CH2:29][OH:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)=[O:21])[C:11]([NH:12][CH:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)=[C:6]2[CH:5]=[N:4]1)[CH3:2]

Komponenten

4

Edukt 3

HCID 112812951-Ethyl-N-[(1R)-2-hydroxy-1-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideHCID 18316484(4-Aminooxan-4-yl)methanolHCID 534878291-Ethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

Produkt 1

HCID 576751931-Ethyl-N-[4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

Versuchsvorschrift

Intermediate 139 was prepared from Intermediate 17 and (4-aminotetrahydro-2H-pyran-4-yl)methanol (commercially available from PharmaCore Inc., 4170 Mendenhall Oaks Pkwy, Suite 140, High point, N.C., USA) using an analogous method to that for Intermediate 42. LCMS showed MH+=404, TRET=2.19 min.

Aufarbeitung

  1. customMH+=404, TRET=2.19 min.

Quellen und Nachweise

ORD-Eintrag
ord-31e5046357f5475c91c21b62a818d1cb
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528148B2

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