HCID 67376231, Verbindung → HCID 86608784, Verbindung

HRID 490923Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 490923
[CH2:1]([O:3][C:4](=[O:24])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])=[CH:9][CH:8]=1)=[CH2:6])[CH3:2].[C:25]([OH:28])(=[S:27])[CH3:26]>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:24])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])=[CH:9][CH:8]=1)[CH2:6][S:27][C:25](=[O:28])[CH3:26])[CH3:2]

Komponenten

4

Edukt 2

HCID 67376231HCID 67376231, VerbindungHCID 178418634HCID 178418634, Verbindung

Produkt 1

HCID 86608784HCID 86608784, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A solution of 2-(4-(benzyloxycarbonylamino)phenyl)prop-2-enoic acid ethyl ester (2.2 g, 7.55 mmol) and thioacetic acid (5 mL) in 10 mL of chloroform was heated for 18 hours. The reaction mixture was evaporated in vacuo and purified by flash chromatography through silica gel (5/1 hexanes/ethyl acetate) to afford 2-(4-(benzyloxycarbonylamino)phenyl)-3-(acetylthio)propanoic acid ethyl ester, 0.22 g (8%) as an oil.

Aufarbeitung

  1. customThe reaction mixture was evaporated in vacuo
  2. custompurified by flash chromatography through silica gel (5/1 hexanes/ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-05734a6f77864d0f8d0772c1467282b5
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528173B2

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