Hydrochloric Acid → Methyl 4-Iodophenylacetate

HRID 490989

Reaktionsgleichung

Reaktionsgleichung von HRID 490989
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.Cl.[CH3:13]O>O1CCOCC1>[I:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:13])=[O:10])=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1372144-Iodophenylacetic acid

Produkt 1

HCID 10378700Methyl 4-IodophenylacetateAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a stirred solution of 4-iodophenylacetic acid (5.0 g, 19.1 mmol) in MeOH (200 mL) was added 4N hydrochloric acid in dioxane (10 mL). The reaction mixture was stirred for 24 h at room temperature and then the solvent was removed under reduced pressure to give the title compound (5.17 g, 98% yield), which was used without further purification.

Aufarbeitung

  1. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-15ce9d6f095f4c6ebd484d396d6f8dd3
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07528253B2

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