Citric Acid → 4-Hydroxy-3-(trifluoromethyl)benzoic acid

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

10.0 g (45.4 mmol) 4-methoxy-3-trifluoromethyl-benzoic acid and 75 g pyridinium-hydrochloride were mixed well and then heated to 180° C. under a nitrogen atmosphere for 5 h. The reaction mixture was poured onto 1 L 10% citric acid solution and extracted with 50 mL EtOAc. The organic phase was washed with 1 L water and dried over Na2SO4. After the desiccant and solvent had been eliminated the product was further reacted without purification.

Herkunft & Nachweise