Ethyl trifluoroacetate → 2,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamide

Temperatur

22 °C

To a stirred solution of morpholin-2-ylmethylamine (3.1 g) in methanol (70 ml) under nitrogen was added an ethereal solution of ethyl-α,α,α-trifluoroacetate (5 ml in 20 ml ether) which had been washed with saturated aqueous sodium bicarbonate, water and brine, and dried. The mixture was stirred for 30 min at 22° C. before removal of all volatiles in vacuo. The residue was dissolved in methanol (10 ml) and the volatiles again removed in vacuo to give the title compound as a white crunchy foam (4.9 g).

1. washhad been washed with saturated aqueous sodium bicarbonate, water and brine
2. customdried
3. dissolutionThe residue was dissolved in methanol (10 ml)
4. customthe volatiles again removed in vacuo

ORD-Eintrag

ord-845b7cb7666c41b9af897208a284404b

Quelldatensatz

uspto-grants-2009_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07531651B2