tert-Butyl 4-(1-(2,4-dimethoxybenzyl)-1,2-dihydro-2-oxopyrido[2,3-d]pyrimidin-3(4H)-yl)piperidine-1-carboxylate → 3-Piperidin-4-yl-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one

HRID 493614

Reaktionsgleichung

COC1C=C(OC)C=CC=1C[N:6]1[C:11]2[N:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH2:9][N:8]([CH:16]2[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]2)[C:7]1=[O:29]>FC(F)(F)C(O)=O>[NH:19]1[CH2:18][CH2:17][CH:16]([N:8]2[CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[N:12][C:11]=3[NH:6][C:7]2=[O:29])[CH2:21][CH2:20]1

Komponenten

Reaktionsbedingungen

Temperatur: 50 °C

Versuchsvorschrift

tert-Butyl 4-[1-(2,4-dimethoxybenzyl)-2-oxo-1,4-dihydropyrido[2,3-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate (0.21 g, 0.43 mmol) was dissolved in trifluoroacetic acid (5 mL) and stirred overnight. The reaction was then heated to 50° C. for 3 h and concentrated to afford the bisTFA salt of the title compound (0.11 g). MS 233.3 (M+1).

Aufarbeitung

concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag: ord-3c4706d13b654c948dce43625c203120
Quelldatensatz: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07534784B2

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