7-Aminoquinoline → 3-Methyl-4-(4-pyridyl)-N-quinolin-7-ylbenzamide
Reaktionsgleichung
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1)[C:16](O)=[O:17]>>[CH3:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1)[C:16]([NH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1)=[O:17]Komponenten
3
Versuchsvorschrift
Using the procedure outlined in Example 56, the title compound was prepared from 7-aminoquinoline (D55) (25 mg, 0.17 mmol) and 3-methyl-4-(4-pyridyl)benzoic acid (D57) (44 mg, 0.21 mmol) as an orange solid. 1H NMR (400 MHz, CDCl3) δ (ppm): 8.91(dd, 1H), 8.70 (d, 2H), 8.22 (m, 2H), 8.14 (dd, 1H), 8.11 (dd, 1H), 7.84 (m, 3H), 7.36 (m, 2H), 7.28 (m, 2H), 2.37 (s, 3H).
Quellen und Nachweise
- ORD-Eintrag
- ord-351c506d168e4fbfac030bd645e35275
- Quelldatensatz
- uspto-grants-2009_05