7-Aminoquinoline → HCID 57682696, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:12][C:13]1[N:21]=[C:20]([C:22]2[S:23][CH:24]=[CH:25][CH:26]=2)[CH:19]=[CH:18][C:14]=1[C:15](O)=[O:16]>>[CH3:12][C:13]1[N:21]=[C:20]([C:22]2[S:23][CH:24]=[CH:25][CH:26]=2)[CH:19]=[CH:18][C:14]=1[C:15]([NH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1)=[O:16]Komponenten
3
Versuchsvorschrift
Using the procedure outlined in Example 45, the title compound was prepared from 7-aminoquinoline (D55) (7 mg, 0.05 mmol) and 2-methyl-6-(2-thienyl)-nicotinic acid (10 mg, 0.05 mmol) as a yellow solid. 1H NMR (400 MHz, MeOH-d4) δ (ppm): 8.82 (dd, 1H), 8.58 (s, 1H), 8.34 (dd, 1H), 7.85-8.0 (m, 3H), 7.76 (m, 2H), 7.55 (dd, 1H), 7.48 (dd, 1H), 7.16 (dd, 1H), 2.70 (s, 3H).
Quellen und Nachweise
- ORD-Eintrag
- ord-e9aff8ec0031424a81da8ac9d5e03dd9
- Quelldatensatz
- uspto-grants-2009_05