HCID 22326467, Verbindung → [3-(Furan-2-yl)phenyl]acetic acid

HRID 495353Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 495353
C[O:2][C:3](=[O:16])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[O:12][CH:13]=[CH:14][CH:15]=2)[CH:6]=1>CO.[OH-].[Na+]>[O:12]1[CH:13]=[CH:14][CH:15]=[C:11]1[C:7]1[CH:6]=[C:5]([CH2:4][C:3]([OH:16])=[O:2])[CH:10]=[CH:9][CH:8]=1

Komponenten

4

Edukt 1

HCID 22326467HCID 22326467, Verbindung

Produkt 1

HCID 22326464[3-(Furan-2-yl)phenyl]acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel2×

Versuchsvorschrift

To a solution of the methyl 3-(2-furanyl)phenylacetate from step (b) in 5 ml of methanol was added 10 ml of 1N NaOH aqueous solution, the resulting solution was stirred overnight before diluting with 40 of ml 1N NaOH aqueous solution and washing with 2×30 ml CH2Cl2. The aqueous solution was then acidified with 2N HCl, and extracted with 3×30 ml of CH2Cl2. The organic extracts were combined and were dried with MgSO4, filtered, and evaporated to give 0.32 g of the product as a golden-colored solid.

Aufarbeitung

  1. washwashing with 2×30 ml CH2Cl2
  2. extractionextracted with 3×30 ml of CH2Cl2
  3. dry with materialwere dried with MgSO4
  4. filtrationfiltered
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-78ce39afe67c441d8cb338e3a1004cbf
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06939861B2

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