HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetamidomalonic acid diethyl ester → N-acetyl-2-ethoxycarbonyl-3-(4-methoxyphenyl)proline ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetamidomalonic acid diethyl ester | HCID 14041 | — |
| Edukt | 3-(4-Methoxyphenyl)prop-2-enal | HCID 230995 | — |
| Produkt | N-acetyl-2-ethoxycarbonyl-3-(4-methoxyphenyl)proline ethyl ester | HCID 10021599 | 79,5% |
Reaktionsschritte
N-Acetyl-2-ethoxycarbonyl-3-(4-methoxyphenyl)proline, ethyl ester (13 g, 72%) was prepared from 4-methoxycinnamaldehyde (Lancaster, 8.1 g, 50 mmol) and diethyl acetamidomalonate (Aldrich, 9.9 g, 45 mmol) by the procedure described by Chung et al (J. Org. Chem. 1990, 55, 270).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06943180B2 |
| Quelldatensatz | uspto-grants-2005_09 |
| ORD ID | ord-29f119994b164dc189e90a8054097d9b |
| Quellennotiz | uspto-grants-2005_09 |