Magnesium → HCID 22324841, Verbindung

Reaktionsgleichung

CO[C:3]1[C:8]([O:9][CH3:10])=[CH:7][CH:6]=[CH:5][C:4]=1[C:11]1[O:12]CC(C)(C)N=1.Br[CH2:19][CH2:20][C:21]1[CH:25]=[CH:24][S:23][CH:22]=1.[Mg]>>[CH3:10][O:9][C:8]1[C:3]([CH2:19][CH2:20][C:21]2[CH:25]=[CH:24][S:23][CH:22]=2)=[C:4]([CH2:11][OH:12])[CH:5]=[CH:6][CH:7]=1

Komponenten

Edukt 3

HCID 5462224Magnesium

HCID 108779483-(2-bromoethyl)thiophene

HCID 111282672-(2,3-Dimethoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole

Produkt 1

HCID 22324841HCID 22324841, Verbindung

Versuchsvorschrift

Using the method of example 44, steps 1-3, with 2-(2,3-dimethoxyphenyl)-4,4-dimethyl-2-oxazoline (J. Org. Chem. 43, 1372 (1978) and the Grignard reagent prepared from 1-bromo-2-(3-thiophenyl)ethane and magnesium the title compound was prepared and the structure confirmed by NMR spectroscopy. 4. 3-[2-(2-Bromomethyl-6-methoxy-phenyl)-ethyl]-thiophene

Quellen und Nachweise

ORD-Eintrag: ord-706adb0dae9c4425911b21dceca1ad7f
Quelldatensatz: uspto-grants-2005_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06943183B2

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