Imidazole → HCID 69735309, Verbindung

HRID 496421

Reaktionsgleichung

Reaktionsgleichung von HRID 496421
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.N1C=CC=CC=1.[CH2:12]1[O:20][C@@H:13]1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)C>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:12][C@H:13]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[OH:20]

Komponenten

5

Edukt 3

HCID 795ImidazoleHCID 1049PyridineHCID 114705(+)-Styrene oxide

Produkt 1

HCID 69735309HCID 69735309, VerbindungAusbeute 32 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In a manner similar to that of Example 49, step 1, imidazole (2.83 g, 41.6 mmol) is dissolved in absolute ethanol (45 mL). Pyridine (0.11 mL) is added followed by addition of (R)-(+) styrene oxide (5.0 g, 41.6 mol, Aldrich Chemical Co.), followed by heating at reflux for 18 hours. The mixture is evaporated in vacuo to a syrup and suspended between ethyl ether (250 mL) and water (100 mL) to give a solid precipitate. The suspension is filtered and washed with ethyl ether. The solid is recrystallized from hot ethyl acetate and dried in vacuo (2.52 g, 32% yield). MS: APCI: M+1, 189.1 (M: 188.2). NMR spectrum is consistent with structure.

Aufarbeitung

  1. temperatureby heating
  2. temperatureat reflux for 18 hours
  3. customThe mixture is evaporated in vacuo to a syrup
  4. customto give a solid precipitate
  5. filtrationThe suspension is filtered
  6. washwashed with ethyl ether
  7. customThe solid is recrystallized from hot ethyl acetate
  8. customdried in vacuo (2.52 g, 32% yield)

Quellen und Nachweise

ORD-Eintrag
ord-150e80cf7b2f4adaa9053a82b1eba305
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06943183B2

Verknüpfte Notizen

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