Methanol → Methyl 2-Bromo-4-nitrobenzoate
Reaktionsgleichung
[Br:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:14]O>>[Br:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:14])=[O:5]Komponenten
3
Versuchsvorschrift
Compound 26 in methanol was treated with SO2Cl2 and the resulting solution heated at reflux for18 h. The reaction mixture was then evaporated, pre-absorbed on silica (Merck, 9385) and purified by chromatography, eluting with 10% ethyl acetate/i-hexane. Appropriate fractions were combined and evaporated to give methyl 2-bromo-4-nitro-benzoate (compound 27).
Aufarbeitung
- temperaturethe resulting solution heated
- temperatureat reflux for18 h
- customThe reaction mixture was then evaporated
- custompre-absorbed on silica (Merck, 9385)
- custompurified by chromatography
- washeluting with 10% ethyl acetate/i-hexane
- customevaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-dff9c183e7ac4755bae7a188497d9847
- Quelldatensatz
- uspto-grants-2005_09
- Patentnummer
- US06946468B1
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