Trifluoroacetic acid → [4-(2-Aminoethyl)-1-piperazinyl](3,4-dichlorophenyl)methanone trifluoroacetate
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][C:25]=1[Cl:26])[C:5]([N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][NH:15]C(=O)OC(C)(C)C)[CH2:9][CH2:8]1)=[O:6].[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30]>ClCCl>[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[NH2:15][CH2:14][CH2:13][N:10]1[CH2:11][CH2:12][N:7]([C:5]([C:4]2[CH:23]=[CH:24][C:25]([Cl:26])=[C:2]([Cl:1])[CH:3]=2)=[O:6])[CH2:8][CH2:9]1Komponenten
4
Versuchsvorschrift
The product from step (ii) above (3.3 g) was dissolved in dichloromethane (50 ml) and trifluoroacetic acid (10 ml) added. After 16 hours at room temperature the solvent was removed to give the sub-titled product as an oil (5.9 g).