1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → t-Butyl 3-(Cbz-Val-amido)-5-fluoro-4-liydroxy-pentanoate

HRID 496987Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 496987
[C:1]([NH:11][C@H:12]([C:16]([OH:18])=O)[CH:13]([CH3:15])[CH3:14])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].CN(C)CCCN=C=NCC.O.ON1C2C=CC=CC=2N=N1.CN(C1C=CC=CN=1)C.[NH2:50][CH:51]([CH:60]([OH:63])[CH2:61][F:62])[CH2:52][C:53]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])=[O:54]>C1COCC1>[C:1]([NH:11][C@H:12]([C:16]([NH:50][CH:51]([CH:60]([OH:63])[CH2:61][F:62])[CH2:52][C:53]([O:55][C:56]([CH3:57])([CH3:58])[CH3:59])=[O:54])=[O:18])[CH:13]([CH3:14])[CH3:15])([O:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)=[O:2]

Komponenten

7

Edukt 5

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 218852-DimethylaminopyridineHCID 726987N-Carbobenzoxy-L-valineHCID 27960291-Hydroxybenzotriazole hydrateHCID 108566723-Amino-5-fluoro-4-hydroxy-pentanoic acid tert-butyl ester

Produkt 1

HCID 21137005t-Butyl 3-(Cbz-Val-amido)-5-fluoro-4-liydroxy-pentanoateAusbeute 68 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To a solution of Cbz-Valine (396 mg, 1.58 mmol) in THF (20 mL) was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDCI) (300 mg, 1.57 mmol), 1-hydroxybenzotriazole hydrate (HOBT) (240 mg, 1.57 mmol) and dimethylaminopyridine (DMAP) 129 mg 1.06 mmol). The resulting mixture was stirred for 5 min, then was added a solution of t-butyl 3-amino-5-fluoro-4-hydroxy-pentanoate (215 mg, 1.04 mmol) in THF (10 mL) and it was stirred at rt for 18 h. The mixture was filtered and the THF solution was evaporated, and the residue was purified by chromatography over silica gel (hexane-EtOAc, 3:2) to give 290 mg (68%) of the titled compound as a white solid. 1HNMR (CDCl3), 0.905 (d, 3H, J=7), 0.965 (d, 3H, J=7), 1.428 (s, 9H), 2.07-2.16 (m, 1H), 2.50-2.57 (m, 1H), 2.64-2.70 (m, 1H), 3.52 (bs, 1H, OH), 3.92-3.96 (m, 2H), 4.20-4.27 (m, 1H), 4.40 (bs, 1H),4.49 (bs, 1H), 5.10 (s, 2H), 5.31-5.4 (m, 1H, NH), 6.86-6.93 (m, 1H, NH), 7.350(s, 5H).

Aufarbeitung

  1. stirringwas stirred at rt for 18 h
  2. filtrationThe mixture was filtered
  3. customthe THF solution was evaporated
  4. customthe residue was purified by chromatography over silica gel (hexane-EtOAc, 3:2)

Quellen und Nachweise

ORD-Eintrag
ord-9d9bf01df466488c86c35b9ebfe65d99
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949516B2

Notizen zur Reaktion

Wird geladen…