Hydrochloric Acid → (RS) 3-(6-amino-pyrid-3-yl)-butanoic acid hydrochloride

Reaktionsgleichung

C([NH:4][C:5]1[N:10]=[CH:9][C:8]([CH:11]([CH3:18])[CH2:12][C:13]([O:15]CC)=[O:14])=[CH:7][CH:6]=1)(=O)C.[ClH:19]>>[ClH:19].[NH2:4][C:5]1[N:10]=[CH:9][C:8]([CH:11]([CH3:18])[CH2:12][C:13]([OH:15])=[O:14])=[CH:7][CH:6]=1

Komponenten

Edukt 2

HCID 313Hydrochloric Acid

HCID 17946644(RS) ethyl 3-(6-acetylamino-pyrid-3-yl)-butanoate

Produkt 1

HCID 69687733(RS) 3-(6-amino-pyrid-3-yl)-butanoic acid hydrochloride

Versuchsvorschrift

A solution of (RS) ethyl 3-(6-acetylamino-pyrid-3-yl)-butanoate (25.56 g, Reference Example 21) in aqueous hydrochloric acid (500 mL, 6M) was heated at 100° C. for 3.5 hours, then cooled and then evaporated to give the title compound as a crystalline solid.

Aufarbeitung

temperaturecooled
customevaporated

Quellen und Nachweise

ORD-Eintrag: ord-6982c1d35e444c62b2ca924c5617f84e
Quelldatensatz: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06706738B2

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