Hydrogen Bromide → HCID 69735974, Verbindung

HRID 497387Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 497387
C[O:2][C:3]([C:5]1[C:16]2[C:15]3[N:11]([CH:12]=[CH:13][N:14]=3)[CH2:10][CH2:9][C:8]=2[NH:7][CH:6]=1)=[O:4].[BrH:17]>>[BrH:17].[N:14]1[CH:13]=[CH:12][N:11]2[C:15]=1[C:16]1[C:5]([C:3]([OH:4])=[O:2])=[CH:6][NH:7][C:8]=1[CH2:9][CH2:10]2

Komponenten

3

Edukt 2

HCID 260Hydrogen BromideHCID 20605631HCID 20605631, Verbindung

Produkt 1

HCID 69735974HCID 69735974, Verbindung

Versuchsvorschrift

A solution of 5,6-dihydro-4H-1,3a,6-triaza-as-indacene-8-carboxylic acid methyl ester (516 mg) and 48% hydrobromic acid (5 mL) is heated at 60° for 60 hours. The mixture is cooled to room temperature and concentrated in vacuo. The residue is slurried with diethyl ether and the ether is decanted off. This is repeated until no more color is visible in the ether layer. The remaining solid is dried in vacuo to give 5,6-dihydro-4H-1,3a,6-triaza-as-indacene-8-carboxylic acid hydrobromide, 350 mg, brown solid: 1H NMR(DMSO-d6) 3.17 (2H, t), 4.40 (2H, t), 7.35 (1H, d), 7.57 (1H, d), 7.63 (1H, s), 12.34 (1H, s), 12.45 (1H, s).

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. customthe ether is decanted off
  3. customThe remaining solid is dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6f7025ef8b134be0b03286e5ce9b585e
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949562B2

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