Sodium Hydroxide → HCID 178433901, Verbindung

HRID 497949Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 497949
[OH:1][C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[CH:6][N:5]=[C:4]2[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:14]=[C:15]([CH3:16])[C:3]=12.[OH-].[Na+]>Cl>[OH:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[C:4]2[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:14]=[C:15]([CH3:16])[C:3]=12

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 178469580HCID 178469580, Verbindung

Produkt 1

HCID 178433901HCID 178433901, VerbindungAusbeute 33,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A suspension of ethyl 4-hydroxy-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (2.0 g, 6.7 mmol) in 6N hydrochloric acid solution (10 mL) was heated and stirred at 100° C. for 1 hour. The solution was cooled to room temperature, made weakly acidic by the addition of an aqueous sodium hydroxide solution, and the resulting precipitate was collected by filtration. The crude crystals thus obtained were washed with water and dried to give the title compound (0.6 g, 33% yield).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureThe solution was cooled to room temperature
  3. filtrationthe resulting precipitate was collected by filtration
  4. customThe crude crystals thus obtained
  5. washwere washed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-99b1e2b8f93c4d12ade94fe950e238e3
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949648B2

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