HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Pentyn-1-ol → 5-(2,5-Dichlorophenyl)pent-4-yn-1-ol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Pentyn-1-ol | HCID 79346 | — |
| Edukt | 1,4-Dichloro-2-iodobenzene | HCID 122452 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Lösungsmittel | Diethylamine | HCID 8021 | — |
| Produkt | 5-(2,5-Dichlorophenyl)pent-4-yn-1-ol | HCID 22320759 | — |
Reaktionsschritte
A solution of 1,4-dichloro-2-iodobenzene (20.0 g, 73.3 mmol), 4-pentyn-1-ol (6.17 g, 73.3 mmol), bistriphenylphosphine(Pd II) chloride (1.03 g, 1.47 mmol), and copper(I) iodide (0.14 g, 0.733 mmol) in 400 ml of diethylamine was stirred under nitrogen for three days. This was diluted with dichloromethane and the oily layer was adsorbed onto silica gel and eluted with hexanes-ethyl acetate (5:1) to give 5-(2,5-dichlorophenyl)-pent-4-yn-1-ol, 13.7 g (82%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06949661B2 |
| Quelldatensatz | uspto-grants-2005_09 |
| ORD ID | ord-1c92ac693c7b40e094bdffd1d594781e |
| Quellennotiz | uspto-grants-2005_09 |