Stannous chloride dihydrate → (2-Amino-5-cyclopropyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

HRID 498225

Reaktionsgleichung

Reaktionsgleichung von HRID 498225
[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[C:12]([CH:14]2[CH2:16][CH2:15]2)[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[N+:21]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[C:12]([CH:14]2[CH2:16][CH2:15]2)[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:2])[CH3:3]

Komponenten

3

Edukt 2

HCID 61436Stannous chloride dihydrateHCID 69489771(5-Cyclopropyl-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

Produkt 1

HCID 69489287(2-Amino-5-cyclopropyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester

Versuchsvorschrift

The title compound was prepared from (5-cyclopropyl-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example A31) (460 mg, 1.33 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as an orange solid (300 mg, 71%).

Quellen und Nachweise

ORD-Eintrag
ord-6f43cdd9ae8442aaa45d53dad143e643
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949542B2

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