Triethylamine → HCID 22741883, Verbindung

HRID 49823

Reaktionsgleichung

Reaktionsgleichung von HRID 49823
Cl[C:2]1[CH:15]=[CH:14][C:5]([C:6]([O:8][CH2:9][CH2:10][N:11]([CH3:13])[CH3:12])=[O:7])=[CH:4][C:3]=1[N+:16]([O-:18])=[O:17].[C:19]([N:22]1[CH2:27][CH2:26][N:25]([C:28]2[CH:29]=[C:30]([CH:32]=[CH:33][CH:34]=2)[NH2:31])[CH2:24][CH2:23]1)(=[O:21])[CH3:20].C(N(CC)CC)C>CN1C(=O)CCC1>[N+:16]([C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][C:2]=1[NH:31][C:30]1[CH:32]=[CH:33][CH:34]=[C:28]([N:25]2[CH2:24][CH2:23][N:22]([C:19](=[O:21])[CH3:20])[CH2:27][CH2:26]2)[CH:29]=1)[C:6]([O:8][CH2:9][CH2:10][N:11]([CH3:13])[CH3:12])=[O:7])([O-:18])=[O:17]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 111175391-[4-(3-Aminophenyl)piperazin-1-yl]ethan-1-oneHCID 22330194HCID 22330194, Verbindung

Produkt 1

HCID 22741883HCID 22741883, VerbindungAusbeute 24,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of 2-(dimethylamino)ethyl 4-chloro-3-nitrobenzoate (2.5 g, 9.1 mmol) and 2d (2.0 g, 9.1 mmol) in anhydrous NMP (5 ml) was added triethylamine (1.3 ml, 9.1 mmol), and the mixture was stirred at 80° C. for 4 hours. The cooled mixture was poured into ice-water (100 ml) and extracted with ethyl acetate (4×20 ml). The combined organic extracts were dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by column-chromatography on silica gel using a mixture of dichloromethane and methanol (9:1 v/v) as the eluent to yield 2-(dimethylamino)ethyl 3-nitro-4-(3-(1-acetylpiperazin-4-yl)anilino)benzoate (1 g, 24%). This intermediate product was dissolved in ethanol (50 ml) and was hydrogenated quantitatively at ambient pressure, using Pd (5% on activated carbon) as the catalyst. The resulting diamine was dissolved in THF (50 ml) and triethyl orthoformate (0.7 ml, 4.2 mmol) was added, together with a catalytic amount of pTSA. The mixture was heated to reflux for 1 hour. The solvent was removed under reduced pressure and the residue was partitioned between aqueous sodium carbonate (1M) and ethyl acetate. The organic phase was dried over sodium sulfate and concentrated under reduced pressure, and the residue was chromatographied on silica gel using a mixture of dichloromethane, methanol and aqueous ammonia (90:10:1) as the eluent. The product isolated from the eluate was treated with activated carbon in refluxing ethanol and the product thus obtained was triturated with petroleum ether to yield 4i (0.18 g, 20%). M.p. 101-103° C.

Aufarbeitung

  1. extractionextracted with ethyl acetate (4×20 ml)
  2. dry with materialThe combined organic extracts were dried over sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by column-chromatography on silica gel using
  5. additiona mixture of dichloromethane and methanol (9:1 v/v) as the eluent

Quellen und Nachweise

ORD-Eintrag
ord-db65a41e358749dabfe2cf2eaeac1d73
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06710044B2

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