Methyl 3-(4-pyridyl)benzoate → 3-Oxo-3-(3-pyridin-4-yl-phenyl)-propionic acid tert-butyl ester

HRID 498230Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 498230
CO[C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[CH:5]=1.[C:17]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])(=[O:19])[CH3:18].[Li]>>[C:21]([O:20][C:17](=[O:19])[CH2:18][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:11]=[CH:12][N:13]=[CH:14][CH:15]=2)[CH:5]=1)([CH3:24])([CH3:23])[CH3:22]

Komponenten

3

Edukt 2

HCID 5152687Methyl 3-(4-pyridyl)benzoateHCID 86586795Lithium Tert-butyl Acetate

Produkt 1

HCID 694868533-Oxo-3-(3-pyridin-4-yl-phenyl)-propionic acid tert-butyl ester

Versuchsvorschrift

The title compound was prepared from 3-pyridin-4-yl-benzoic acid methyl ester [CAS-No. 126179-78-0] (3.60 g, 16.88 mmol) by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as a yellow oil (3.88 g).

Quellen und Nachweise

ORD-Eintrag
ord-e51cb4b5eb4447de8782a1a462db349b
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949542B2

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