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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 498263Erstellt: 23. Oktober 2026

tert-Butyl (3-amino-2'-fluoro-[1,1'-biphenyl]-4-yl)carbamate → (2'-Fluoro-3-{3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert-butyl ester

https://huagongshe.com/de/reaction/498263

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukttert-Butyl (3-amino-2'-fluoro-[1,1'-biphenyl]-4-yl)carbamateHCID 67361423—
Edukt3-[3-(6-Methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl esterHCID 69489386—
Produkt(2'-Fluoro-3-{3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert-butyl esterHCID 86589228—

Reaktionsschritte

The title compound was prepared from (3-amino-2′-fluoro-biphenyl-4-yl)-carbamic acid tert-butyl ester [CAS-No. 335255-65-7] (227 mg, 0.75 mmol) and 3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K4) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow solid (347 mg).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS06949542B2
Quelldatensatzuspto-grants-2005_09
ORD IDord-b09b53fb79614b34a3776e4f29e760c6
Quellennotizuspto-grants-2005_09