[2-Amino-5-(tetrahydro-pyran-2-yloxymethyl)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester → [2-{3-[3-(2-Methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-(tetrahydro-pyran-2-yloxymethyl)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester

HRID 498460Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 498460
[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]1[CH:13]=[C:12]([CH2:14][O:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][O:17]2)[C:11]([C:22]([F:25])([F:24])[F:23])=[CH:10][C:9]=1[NH2:26])([CH3:4])([CH3:3])[CH3:2].C([O:32][C:33](=O)[CH2:34][C:35]([C:37]1[CH:42]=[CH:41][CH:40]=[C:39]([C:43]2[CH:48]=[CH:47][N:46]=[C:45]([CH3:49])[CH:44]=2)[CH:38]=1)=[O:36])(C)(C)C>>[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]1[CH:13]=[C:12]([CH2:14][O:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][O:17]2)[C:11]([C:22]([F:24])([F:25])[F:23])=[CH:10][C:9]=1[NH:26][C:33](=[O:32])[CH2:34][C:35]([C:37]1[CH:42]=[CH:41][CH:40]=[C:39]([C:43]2[CH:48]=[CH:47][N:46]=[C:45]([CH3:49])[CH:44]=2)[CH:38]=1)=[O:36])([CH3:4])([CH3:2])[CH3:3]

Komponenten

3

Edukt 2

HCID 69487195[2-Amino-5-(tetrahydro-pyran-2-yloxymethyl)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl esterHCID 694893073-[3-(2-Methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

Produkt 1

HCID 86589425[2-{3-[3-(2-Methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-(tetrahydro-pyran-2-yloxymethyl)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester

Versuchsvorschrift

The title compound was prepared from [2-amino-5-(tetrahydro-pyran-2-yloxymethyl)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J38) (293 mg, 0.75 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K12) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous yellow substance (168 mg, 36%).

Aufarbeitung

  1. customObtained as an amorphous yellow substance (168 mg, 36%)

Quellen und Nachweise

ORD-Eintrag
ord-4c0e2bad22f349d9ac3af0c86212c779
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949542B2

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