Chlorosuccinimide → ethyl 4-chloro-5-methyl-1H-pyrazole-3-carboxylate

HRID 499254Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 499254
[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:3]=1.[Cl:12]N1C(=O)CCC1=O>CN(C=O)C>[CH2:10]([O:9][C:7]([C:4]1[C:3]([Cl:12])=[C:2]([CH3:1])[NH:6][N:5]=1)=[O:8])[CH3:11]

Komponenten

4

Edukt 2

HCID 31398ChlorosuccinimideHCID 77645Ethyl 5-methyl-1H-pyrazole-3-carboxylate

Produkt 1

HCID 604759ethyl 4-chloro-5-methyl-1H-pyrazole-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a magnetically stirred solution of ethyl 5-methyl-1H-pyrazole-3-carboxylate (3 mmol) in 10 mL of anhydrous DMF at 0° C. is added N-chlorosuccinimide (4 mmol). The solution is stirred at RT for 5 h. The solvent is concentrated to a half of the original volume, water is added and the reaction mixture is allowed to cool over ice. The solid that precipitates is collected by filtration and purified by crystallization to afford 4-chloro-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester as a white solid: m.p. 106-107° C.; 1H-NMR (DMSO-d6) δ 1.25-1.32 (t, 3H J=7 Hz), 2.21 (s, 3H), 4.22-4.32 (q, 2H J=7.2), 13.59 (s, 1H).

Aufarbeitung

  1. concentrationThe solvent is concentrated to a half of the original volume, water
  2. additionis added
  3. temperatureto cool over ice
  4. customThe solid that precipitates
  5. filtrationis collected by filtration
  6. custompurified by crystallization

Quellen und Nachweise

ORD-Eintrag
ord-f4a432f52cb142898fb8ff753632850d
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07767685B2

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