Triethylamine → HCID 68459271, Verbindung

HRID 499294Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 499294
[C:1]([O:10]C)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[SH:4].C(O[C:16]1[CH:17]=[CH:18][C:19]([C:22]#N)=[N:20][CH:21]=1)(=O)C.[C:24]([O:27]C1C(C#N)=NC=CC=1)(=[O:26])[CH3:25].[CH2:36]([N:38](CC)CC)C>C1(C)C=CC=CC=1>[C:24]([O:27][CH2:22][C:19]1[CH:18]=[CH:17][C:16]([C:36]2[S:4][C:3]3[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=3[C:1](=[O:10])[N:38]=2)=[CH:21][N:20]=1)(=[O:26])[CH3:25]

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 21009Benzoic acid, 2-mercapto-, methyl esterHCID 22939311HCID 22939311, VerbindungHCID 229393796-Cyanopyridin-3-yl acetate

Produkt 1

HCID 68459271HCID 68459271, VerbindungAusbeute 29 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of methyl thiosalicylate (0.58 g, 3.43 mmol), a mixture of 5-acetoxy-2-cyanopyridine and 3-acetoxy-2-cyanopyridine (0.60 g, 3.43 mmol), triethylamine (0.72 ml, 5.15 mmol) and toluene (100 ml) was refluxed for 48 hrs as described in Example 1. The solvent was concentrated under reduced pressure. The residue was recrystallized from ethanol to give the titled compound (0.30 g, 29%) as crystals.

Aufarbeitung

  1. temperaturewas refluxed for 48 hrs
  2. concentrationThe solvent was concentrated under reduced pressure
  3. customThe residue was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-ad03d1d635a24a25863678d24c54012e
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07767665B2

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