Hydrochloric Acid → 2-Fluoro-5-trifluoromethylbenzenethiol

HRID 49956Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 49956
C(OC([S:6][C:7]1[CH:8]=[C:9]([C:14]([F:17])([F:16])[F:15])[CH:10]=[CH:11][C:12]=1[F:13])=S)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].Cl>O1CCCC1>[F:13][C:12]1[CH:11]=[CH:10][C:9]([C:14]([F:15])([F:16])[F:17])=[CH:8][C:7]=1[SH:6]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 120973533-Ethoxythiocarbonylthio-4-fluorobenzotrifluorideHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 120973542-Fluoro-5-trifluoromethylbenzenethiol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

The above-obtained 3-ethoxythiocarbonylthio-4-fluorobenzotrifluoride was dissolved in 100 ml of tetrahydrofuran without further purification. The solution was added dropwise to a suspension of 4.4 g of lithium aluminum hydride in 100 ml of tetrahydrofuran. The reaction mixture was stirred for 3 hours, followed by addition of diluted hydrochloric acid to adjust the pH to 1, and the mixture was extracted with ethyl acetate, giving 13 g of 4-fluoro-3-mercaptobenzotrifluoride.

Aufarbeitung

  1. extractionthe mixture was extracted with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-35bc6c280a664c1ba9f36a0b7542836b
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06710062B1

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