Sodium Bicarbonate → Aliskiren

HRID 500016Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 500016
C(OC(=O)[NH:7][C@@H:8]([CH2:26][C@H:27]([CH2:31][C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([O:40][CH2:41][CH2:42][CH2:43][O:44][CH3:45])[CH:33]=1)[CH:28]([CH3:30])[CH3:29])[C@@H:9]([OH:25])[CH2:10][C@H:11]([C:15](=[O:24])[NH:16][CH2:17][C:18]([C:21](=[O:23])[NH2:22])([CH3:20])[CH3:19])[CH:12]([CH3:14])[CH3:13])(C)(C)C.C(=O)(O)[O-].[Na+]>Cl.O1CCOCC1>[NH2:7][C@@H:8]([CH2:26][C@H:27]([CH2:31][C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([O:40][CH2:41][CH2:42][CH2:43][O:44][CH3:45])[CH:33]=1)[CH:28]([CH3:29])[CH3:30])[C@@H:9]([OH:25])[CH2:10][C@@H:11]([CH:12]([CH3:13])[CH3:14])[C:15]([NH:16][CH2:17][C:18]([C:21](=[O:23])[NH2:22])([CH3:20])[CH3:19])=[O:24]

Komponenten

5

Edukt 2

HCID 516892Sodium BicarbonateHCID 53348234tert-Butyl [(3S,5S,6S,8S)-8-[(3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl]-6-hydroxy-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-2,9-dimethyldecan-5-yl]carbamate

Produkt 1

HCID 5493444Aliskiren

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Product 13 is dissolved in a mixture of 4.0M hydrochloric acid in dioxane. The solution is stirred for 24 hours at room temperature and neutralized with solid sodium bicarbonate. The suspension is filtered and the solvent removed in vacuum to give the product as a foam (for characterization see e.g. EP 0 678 503, Example 137).

Aufarbeitung

  1. filtrationThe suspension is filtered
  2. customthe solvent removed in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ab4596c6eae7472bb5bd1d8be44d3a6c
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07767831B2

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