HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Cyanide → 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Cyanide | HCID 8929 | — |
| Edukt | 1-Benzyl-4-piperidone | HCID 19220 | — |
| Edukt | Piperidine, hydrochloride (1:1) | HCID 2723721 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile | HCID 2733434 | 95,4% |
Reaktionsschritte
A solution of 5.3 g of sodium cyanide in 20 ml of water is added dropwise at RT to a solution of 18.9 g of 1-benzylpiperid-4-one and 12.16 g of piperidine hydrochloride in 25 ml of MeOH and 25 ml of water and the mixture is stirred for 48 hours at RT. The precipitate formed is filtered off, washed with water and dried under vacuum to give 27 g of the expected product.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06710042B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-c1e494c1679f413993b9aba28b5ed289 |
| Quellennotiz | uspto-grants-2004_03 |