Acetyl chloride → Ethyl 6-oxo-1,6-dihydropyridazine-4-carboxylate

HRID 500536Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 500536
[O:1]=[C:2]1[NH:7][N:6]=[CH:5][C:4]([C:8]([OH:10])=[O:9])=[CH:3]1.[C:11](Cl)(=O)[CH3:12]>C(O)C>[CH2:11]([O:9][C:8]([C:4]1[CH:5]=[N:6][NH:7][C:2](=[O:1])[CH:3]=1)=[O:10])[CH3:12]

Komponenten

4

Edukt 2

HCID 6367Acetyl chlorideHCID 123762656-Oxo-1,6-dihydropyridazine-4-carboxylic acid

Produkt 1

HCID 12376258Ethyl 6-oxo-1,6-dihydropyridazine-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

The title compound from Example 18.3 (1.0 g, 7.13 mmol) was added to a solution of ethanol (16 mL) and acetyl chloride (4 mL) and the resulting suspension was heated to 75° C. and stirred overnight. The reaction mixture was concentrated, diluted with water and extracted with dichloromethane. The organic phase was dried over sodium sulfate, filtered and concentrated to give the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. additiondiluted with water
  3. extractionextracted with dichloromethane
  4. dry with materialThe organic phase was dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-3aa33dedd9b04de8a50ea781e5e0a20b
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772235B2

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