Allyl bromide → 3-Allyloxy-2,6-dichloro-benzaldehyde

HRID 500613Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 500613
[Cl:1][C:2]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]([Cl:11])[C:3]=1[CH:4]=[O:5].[CH2:12](Br)[CH:13]=[CH2:14].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:14]([O:10][C:9]1[C:2]([Cl:1])=[C:3]([C:6]([Cl:11])=[CH:7][CH:8]=1)[CH:4]=[O:5])[CH:13]=[CH2:12]

Komponenten

5

Edukt 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 104425302,6-Dichloro-3-hydroxy-benzaldehyde

Produkt 1

HCID 866124013-Allyloxy-2,6-dichloro-benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2,6-dichloro-3-hydroxybenzaldehyde (960 mg, 5.03 mmol) (Synthesis, 2004, 12, 2062), allyl bromide (431 μL, 5.03 mmol) and potassium carbonate (563 mg, 10.06 mmol) were combined in DMF (5 mL) and stirred at room temperature for 18 hours. The DMF was removed in vacuo and the residue partitioned between diethyl ether (50 mL) and water (30 mL). The layers were separated and the aqueous extracted with diethyl ether (2×30 mL). The combined organic solution was dried over magnesium sulphate and concentrated in vacuo to afford the title compound as a yellow solid which was used without further purification in preparation 75.

Aufarbeitung

  1. customThe DMF was removed in vacuo
  2. customthe residue partitioned between diethyl ether (50 mL) and water (30 mL)
  3. customThe layers were separated
  4. extractionthe aqueous extracted with diethyl ether (2×30 mL)
  5. dry with materialThe combined organic solution was dried over magnesium sulphate
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cb8075cf0150448183c394c40d345740
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772223B2

Notizen zur Reaktion

Wird geladen…