Potassium Carbonate → 3-[3-[4-(2-Aminothiazol-4-yl)-4-phenylpiperid-1-yl-]propyl]-1-benzoyl-3-(3,4-dichlorophenyl)perhydroazepine dihydrochloride

HRID 50070

Reaktionsgleichung

Reaktionsgleichung von HRID 50070
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[N:6]=1.[ClH:19].C(N(C1(C2C=CC=CC=2)CCN([CH2:31][CH2:32][CH2:33][C:34]2([C:49]3[CH:54]=[CH:53][C:52]([Cl:55])=[C:51]([Cl:56])[CH:50]=3)[CH2:40][CH2:39][CH2:38][CH2:37][N:36]([C:41](=[O:48])[C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=3)[CH2:35]2)CC1)C)(=O)C.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.C(#N)C>[ClH:55].[ClH:19].[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:8][CH2:9][N:10]([CH2:31][CH2:32][CH2:33][C:34]3([C:49]4[CH:54]=[CH:53][C:52]([Cl:55])=[C:51]([Cl:56])[CH:50]=4)[CH2:40][CH2:39][CH2:38][CH2:37][N:36]([C:41](=[O:48])[C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=4)[CH2:35]3)[CH2:11][CH2:12]2)[N:6]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 227417264-(2-Aminothiazol-4-yl)-4-phenylpiperidineHCID 227417463-[3-[4-(Acetyl-N-methylamino)-4-phenylpiperid-1-yl]propyl]-1-benzoyl-3-(3,4-dichlorophenyl)perhydroazepine hydrochloride

Produkt 1

HCID 227417193-[3-[4-(2-Aminothiazol-4-yl)-4-phenylpiperid-1-yl-]propyl]-1-benzoyl-3-(3,4-dichlorophenyl)perhydroazepine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21891449acetonitrile N,N-dimethylformamideLösungsmittel

Versuchsvorschrift

This compound is prepared by the procedure described in step D of EXAMPLE 13, starting from 0.77 g of 4-(2-aminothiazol-4-yl)-4-phenylpiperidine (compound of PREPARATION 1.4 in the form of the free base), 1.2 g of the compound obtained in step C of EXAMPLE 13 and 1.2 g of K2CO3 in 20 ml of a DMF/acetonitrile mixture (50/50; v/v). This gives 0.8 g of the expected product after crystallization from AcOEt, m.p.=178° C.

Aufarbeitung

  1. customThis compound is prepared by the procedure
  2. customThis gives 0.8 g of the expected product after crystallization from AcOEt, m.p.=178° C.

Quellen und Nachweise

ORD-Eintrag
ord-c6df22f1889c4041802a2753354318ba
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06710042B2

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