HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,6-Dichloro-4-nitrophenol → (7-(2,6-Dichloro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,6-Dichloro-4-nitrophenol | HCID 12066 | — |
| Edukt | (7-Chlorothieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone | HCID 11173165 | — |
| Edukt | 7-(2-fluoro-4-nitrophenoxy)-N,N-dimethylthieno[3,2-b]pyridine-2-carboxamide | HCID 59424475 | — |
| Produkt | (7-(2,6-Dichloro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)(pyrrolidin-1-yl)methanone | HCID 59424694 | 69% |
Reaktionsschritte
Starting from the compound 139 and following the procedure described above for the synthesis of compound 6 (scheme 1, example 1) but replacing 2-fluoro-4-nitrophenol with 2,6-dichloro-4-nitrophenol, title compound 140 was obtained in 69% yield. LRMS (M+1) 438.0 (100%), 439.1 (20%), 440.1 (70%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07772247B2 |
| Quelldatensatz | uspto-grants-2010_08 |
| ORD ID | ord-5e26d3efa8bf46d7bbaf674d75fe4a30 |
| Quellennotiz | uspto-grants-2010_08 |