7-(2-fluoro-4-nitrophenoxy)-1H-pyrrolo[2,3-c]pyridine → 6-Bromo-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine

HRID 500898Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 500898
[Br:1][C:2]1[C:3](Cl)=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1.[F:12][C:13]1[CH:28]=[C:27]([N+:29]([O-:31])=[O:30])[CH:26]=[CH:25][C:14]=1[O:15]C1N=CC=C2C=CNC=12>>[Br:1][C:2]1[C:3]([O:15][C:14]2[CH:25]=[CH:26][C:27]([N+:29]([O-:31])=[O:30])=[CH:28][C:13]=2[F:12])=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 594246417-(2-fluoro-4-nitrophenoxy)-1H-pyrrolo[2,3-c]pyridineHCID 594246556-Bromo-7-chlorothieno(3,2-b)pyridine

Produkt 1

HCID 594244576-Bromo-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridineAusbeute 61 %

Versuchsvorschrift

Starting from the compound 271 and following the procedure described above for the synthesis of compound 260 (scheme 59, example 218, step 2), title compound 272 was obtained in 61% yield as an off-white solid. MS (m/z): 368.9(M+H).

Quellen und Nachweise

ORD-Eintrag
ord-f869cb4a864344f38124fd6ca783f4b3
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772247B2

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