HCID 22024658, Verbindung → HCID 22024358, Verbindung

HRID 501009Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 501009
[Br:1][C:2]1[C:3]2[N:4]([CH2:8][CH:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[N:6][CH:7]=1>C1(C)C=CC=CC=1.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=2)[CH:5]=[N:6][CH:7]=1

Komponenten

4

Edukt 1

HCID 22024658HCID 22024658, Verbindung

Produkt 1

HCID 22024358HCID 22024358, VerbindungAusbeute 43,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

8-Bromo-2-ethyl-2,3-dihydroimidazo[1,2-c]pyrimidine (3.0 g) was dissolved in toluene (60 mL), then activated manganese (IV) dioxide (3.5 g) was added thereto, and the mixture was heated under stirring at 90° C. for 1 day. Manganese (IV) oxide was filtered off through Celite, and the solvent was evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:10) to give the title compound (1.3 g) as white crystals.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. filtrationManganese (IV) oxide was filtered off through Celite
  3. customthe solvent was evaporated
  4. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1:10)

Quellen und Nachweise

ORD-Eintrag
ord-837f6f46ed2642a38617b9faa8008681
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772249B2

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