Benzyl 3-(tert-butoxycarbonylamino)piperidine-1-carboxylate → 3-(Boc-amino)piperidine

HRID 501417Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 501417
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:14][CH2:13][CH2:12][N:11](C(OCC2C=CC=CC=2)=O)[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[C].[Pd].C(O)C>[NH:11]1[CH2:12][CH2:13][CH2:14][CH:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:3])([CH3:2])[CH3:4])[CH2:10]1

Komponenten

4

Edukt 1

HCID 22258937Benzyl 3-(tert-butoxycarbonylamino)piperidine-1-carboxylate

Produkt 1

HCID 42330413-(Boc-amino)piperidineAusbeute 100,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture consisting of 10 g of benzyl 3-t-butoxycarbonylaminopiperidine-1-carboxylate, 500 mg of 10% palladium carbon and 100 ml of ethanol was stirred at room temperature under a hydrogen atmosphere overnight. The catalyst was removed by filtration. The filtrate was concentrated and dried to give 6.0 g of the title compound.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. concentrationThe filtrate was concentrated
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-6f4daae6bb2a4751a8ad522f5d73c3b4
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772226B2

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