Allylamine → Allyl-(3-nitropyridin-4-yl)amine

HRID 501438Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 501438
[CH2:1]([NH2:4])[CH:2]=[CH2:3].Cl.C(O[C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1[N+:15]([O-:17])=[O:16])C>C(O)C>[CH2:1]([NH:4][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1[N+:15]([O-:17])=[O:16])[CH:2]=[CH2:3]

Komponenten

4

Edukt 2

HCID 7853AllylamineHCID 124074974-Ethoxy-3-nitropyridine--hydrogen chloride (1/1)

Produkt 1

HCID 23070628Allyl-(3-nitropyridin-4-yl)amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

40 ml of allylamine was added to a 400 ml ethanol solution of 18.0 g of 4-ethoxy-3-nitropyridine hydrochloride, and the mixture was heated under reflux for 8 hours. The reaction solution was concentrated under reduced pressure. The residue was purified by silica gel column chromatography. Thus, 13.6 g of the title compound was obtained from the fraction eluted with ethyl acetate-hexane (1:1).

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 8 hours
  3. concentrationThe reaction solution was concentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-2cb3d33f74d84095ab2981d138ed8864
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772226B2

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