[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH:18]([C:19](O)=[O:20])[CH2:17][CH:16]3[CH2:22][CH2:23][CH2:24][CH:15]23)(=[O:13])=[O:12])=[CH:7][CH:6]=1)(=[O:4])=[O:3].ClC(OCC)=O.C(N1CCOCC1)C.C[Si]([NH:43][OH:44])(C)C>CN(C=O)C>[OH:44][NH:43][C:19]([CH:18]1[N:14]([S:11]([C:8]2[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:6][CH:7]=2)(=[O:13])=[O:12])[CH:15]2[CH2:24][CH2:23][CH2:22][CH:16]2[CH2:17]1)=[O:20]200 mg (0.55 mmol) of 1-(4-methanesulfonylbenzenesulfonyl)octahydrocyclopenta-[b]pyrrole-2-carboxylic acid were dissolved in 10 ml of DMF, after which 0.60 mmol of ethyl chloroformate, 1.22 mmol of N-ethylmorpholine and 1.67 mmol of trimethylsilylhydroxylamine were added. After the mixture had been heated at 80° C. for 4 h, the solvent was removed under reduced pressure and the crude product was purified using chromatographic methods.
Wird geladen…