Hydrochloric Acid → 4-(3,5-Dichloro-phenyl)-6-[(6chloro-pyridin-3-yl)-hydroxy-(3-methyl-3h-imidazol4-yl)-methyl]-1h-quinolin-2-one

HRID 50158Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 50158
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]([C:27]4[CH:28]=[N:29][C:30]([Cl:33])=[CH:31][CH:32]=4)([C:21]4[N:22]([CH3:26])[CH:23]=[N:24][CH:25]=4)[OH:20])[CH:17]=3)[N:12]=[C:11]([O:34]C)[CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.Cl>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]([C:27]4[CH:28]=[N:29][C:30]([Cl:33])=[CH:31][CH:32]=4)([OH:20])[C:21]4[N:22]([CH3:26])[CH:23]=[N:24][CH:25]=4)[CH:17]=3)[NH:12][C:11](=[O:34])[CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 22465439[4-(3,5-dichloro-phenyl)-2-methoxy-quinolin-6-yl]-(6-chloro-pyridin-3-yl)-(3-methyl-3H-imidazol-4-yl)-methanol

Produkt 1

HCID 224654294-(3,5-Dichloro-phenyl)-6-[(6chloro-pyridin-3-yl)-hydroxy-(3-methyl-3h-imidazol4-yl)-methyl]-1h-quinolin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Following the same procedure as described in example 1F, [4-(3,5-dichloro-phenyl)-2-methoxy-quinolin-6-yl]-(6-chloro-pyridin-3-yl)-(3-methyl-3H-imidazol-4-yl)-methanol (886 mg, 1.68 mmol) was treated with HCl in aqueous THF to yield the title compound of 16D. It was directly used for the next reaction without further purification.

Quellen und Nachweise

ORD-Eintrag
ord-abe183fdc4214b0c88e90d171ffa3632
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06710209B2

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